Leptin's neural circuit identified

[Northerner]

Revealing surprising answers to a long-standing enigma about the brain target of the anti-obesity hormone leptin, neuroscientists at Tufts University School of Medicine have used CRISPR genome editing to identify a neural circuit in the hypothalamus as the primary mechanism in mediating leptin's anti-obesity and anti-diabetes effects and have identified two distinct mechanisms underlying leptin's inhibition of appetite. The research, which appears online in the journal Nature on April 18, advances efforts to find more effective therapies for obesity, type 1 and type 2 diabetes, and their complications.

Although its award-winning discovery transformed the study of obesity more than 20 years ago, leptin's mechanisms have remained a mystery

https://www.sciencedaily.com/releases/2018/04/180418144716.htm

 

[mikeyB]

Mice again. You know, one of these days they’re going to rise up against us.😱

On a more serious note, I’ll file this under interesting but not useful in diabetes therapy.