Eddy Edson
Well-Known Member
- Relationship to Diabetes
- Type 2
Story: https://www.sciencedaily.com/releases/2023/03/230316114126.htm
Paper: http://dx.doi.org/10.1093/ehjopen/oead008
A big pair of observational studies backed up by a MR study to refine view on causation.
Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours ...
"Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD," said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, Sweden.
"Insufficient night-time sleep and daytime napping have previously been associated with a raised risk of coronary artery disease which, like PAD, is caused by clogged arteries. In addition, sleeping problems are among the top ranked complaints in PAD patients. There are limited data on the impact of sleep habits on PAD and vice versa, and our study aimed to fill that gap."
The study included more than 650,000 participants and was conducted in two parts.3 First, the researchers analysed the associations of sleep duration and daytime napping with the risk of PAD. In the second part, the investigators used genetic data to perform naturally randomised controlled trials -- called Mendelian randomisation -- to examine causality of the associations.
Dr. Yuan said: "Observational analyses are limited by reverse causality -- meaning that if an association between sleep habits and PAD is found, we cannot be certain if sleep habits caused PAD or having PAD caused the sleep habits. Mendelian randomisation is a robust method for evaluating causality and provides more certainty about the results."
Taken together, the strongest evidence was for short sleep, where the relationship with PAD went both ways. In an observational analysis of 53,416 adults, sleeping less than five hours a night was associated with a nearly doubled risk of PAD compared with seven to eight hours (hazard ratio
1.74; 95% confidence interval [CI] 1.31-2.31). This finding was supported by further analyses in 156,582 and 452,028 individuals. In the causal studies, short sleep was associated with an increased risk of PAD and, in addition, PAD was associated with an increased likelihood of short sleep. Dr. Yuan said: "The results indicate that brief night-time sleep can raise the chance of developing PAD, and that having PAD increases the risk of getting insufficient sleep."
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FWIW, I've always had a lot of trouble getting more than about 5 hrs sleep a night. My PAD is really sensitive to the amount of sleep I actually get, in terms of walking performance: I can get 14 MET-hrs exercise from fast walking on a day when I've had 7 hours sleep versus a real effort to walk fast enough to get it to 8 MET-hrs when I've only had 5 hours sleep. There's a real effect & I can well believe that being a bad sleeper may have contributed to me getting PAD sonner than I might have otherwise.
Paper: http://dx.doi.org/10.1093/ehjopen/oead008
A big pair of observational studies backed up by a MR study to refine view on causation.
Sleeping less than five hours a night is associated with a 74% raised likelihood of developing peripheral artery disease (PAD) compared with seven to eight hours ...
"Our study suggests that sleeping for seven to eight hours a night is a good habit for lowering the risk of PAD," said study author Dr. Shuai Yuan of the Karolinska Institute, Stockholm, Sweden.
"Insufficient night-time sleep and daytime napping have previously been associated with a raised risk of coronary artery disease which, like PAD, is caused by clogged arteries. In addition, sleeping problems are among the top ranked complaints in PAD patients. There are limited data on the impact of sleep habits on PAD and vice versa, and our study aimed to fill that gap."
The study included more than 650,000 participants and was conducted in two parts.3 First, the researchers analysed the associations of sleep duration and daytime napping with the risk of PAD. In the second part, the investigators used genetic data to perform naturally randomised controlled trials -- called Mendelian randomisation -- to examine causality of the associations.
Dr. Yuan said: "Observational analyses are limited by reverse causality -- meaning that if an association between sleep habits and PAD is found, we cannot be certain if sleep habits caused PAD or having PAD caused the sleep habits. Mendelian randomisation is a robust method for evaluating causality and provides more certainty about the results."
Taken together, the strongest evidence was for short sleep, where the relationship with PAD went both ways. In an observational analysis of 53,416 adults, sleeping less than five hours a night was associated with a nearly doubled risk of PAD compared with seven to eight hours (hazard ratio
1.74; 95% confidence interval [CI] 1.31-2.31). This finding was supported by further analyses in 156,582 and 452,028 individuals. In the causal studies, short sleep was associated with an increased risk of PAD and, in addition, PAD was associated with an increased likelihood of short sleep. Dr. Yuan said: "The results indicate that brief night-time sleep can raise the chance of developing PAD, and that having PAD increases the risk of getting insufficient sleep."
------------------------------------------------------------------------------------------
FWIW, I've always had a lot of trouble getting more than about 5 hrs sleep a night. My PAD is really sensitive to the amount of sleep I actually get, in terms of walking performance: I can get 14 MET-hrs exercise from fast walking on a day when I've had 7 hours sleep versus a real effort to walk fast enough to get it to 8 MET-hrs when I've only had 5 hours sleep. There's a real effect & I can well believe that being a bad sleeper may have contributed to me getting PAD sonner than I might have otherwise.