Key Cellular Mechanism in Body's 'Battery' Can Either Spur or Stop Obesity

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Becoming obese or remaining lean can depend on the dynamics of the mitochondria, the body's energy-producing "battery," according to two new studies by Yale School of Medicine researchers featured as the cover story in the Sept. 26 issue of the journal Cell.

Mitochondria are vital cellular organelles that generate and maintain proper energy levels in complex organisms. Using animal models, the Yale research team studied mitochondria in different populations of brain cells known to be involved in the regulation of appetite. The team found that during the transition from a fasting to an over-fed state, mitochondria in neurons that promote hunger show dynamic changes that are the opposite of those found in neurons that control feelings of fullness.

http://www.sciencedaily.com/releases/2013/09/130926123336.htm
 
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