Found this on Lantus on the Livestrong site:
Respiratory Effects
Respiratory effects of Lantus in clinical trials were similar to those of NPH, another type of insulin often used to treat diabetes. Side effects that occurred in more than 5 percent of people taking Lantus include upper respiratory infection, runny or stuffy nose, bronchitis, sore throat, cough, influenza and sinusitis, Drugs.com reports.
Fluid Retention
Insulins tend to cause fluid buildup due to retention of sodium, Drugs.com explains. Twenty percent of people taking Lantus reported edema in their arms and legs. High blood pressure, which can be worsened by fluid retention, was reported by 19 percent; headaches, which also can intensify when fluid is retained, were reported by 10 percent.
Skin Reactions
Because Lantus is an injected medication, it can cause skin changes at the site of injection. The skin may thicken or thin at the injection sites, which can change the way the medication is absorbed. Injection sites always should be rotated to decrease the chance of localized skin changes. Pain at the injection site was reported more often with Lantus than with NPH insulin, the University of Maryland Medical Center reports.
Allergic Reactions
Any drug, including Lantus, can cause allergic reactions, which can in some cases be life-threatening. Signs of serious allergic reaction include hives, shortness of breath, swelling of the face especially around the mouth, throat and tongue, difficulty breathing and collapse. Immediate medical attention is required if a severe allergic reaction occurs. Milder reactions such as a rash at the injection site or an overall rash and itching should be reported to your doctor; antihistamines may be used to treat mild allergic symptoms.
