Insulin production restored in cells from Type 1

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Amity Island

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Relationship to Diabetes
Type 1
“These results support the notion that EZH2 inhibition restores exocrine multipotency even in chronic disease with total β-cell destruction,” the researchers wrote. In other words, treating the ductal cells with the drug GSK126 caused them to functionally resemble β cells and to produce insulin.

In principle, this new approach would allow insulin-producing β cells that are destroyed in T1D patients to be replaced with new insulin-generating cells. “We consider the research novel and an important step forward towards developing new therapies,” El-Osta said.


 
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