Insulin Degludec Matches Insulin Glargine Efficacy

[Northerner]

Insulin degludec, an ultralong-acting insulin now in clinical development, proved noninferior to insulin glargine in two parallel, phase III randomized trials sponsored by the manufacturer and reported in the April 21 issue of Lancet.

The new insulin was as effective as insulin glargine at reducing hemoglobin A1c levels in one study of patients with type 1 diabetes and in another of patients with type 2 diabetes. Patients reported significantly fewer episodes of hypoglycemia with insulin degludec, both research groups reported.

Fear of hypoglycemic events often interferes with patients? initiating or intensifying their insulin therapy, and may be the leading cause of inadequate insulin dosing, the researchers noted.

When injected subcutaneously, insulin degludec forms a depot of soluble multihexamers that slowly and continuously release the drug into the circulation. Insulin degludec has a half-life of 25 hours (twice that of insulin glargine) and a duration of action of more than 40 hours.

http://www.familypracticenews.com/n...hes-insulin-glargine-efficacy/f809a87ca0.html

 

[Robster65]

That would be interesting to try and work into a daily routine 😱

I presume it would need a full dose one day and a 'top up' the next. Not easy to manage unless it has a slow ramp up as well as ramp down.

Rob

 

[trophywench]

Hmmmmmm.

What do they mean '80% of all the patients displayed any symptoms of hypo' - were they actually having hypos or just ticking the box to say they were hypo-aware still? LOL

It said they were all taking a single jab daily, mostly at bedtime. Wouldn't you be a bit worried driving to work, knowing you injected the night before the night before, as well as the night before and there was still even now about 6 - 8 hours to run on the original jab? (you injected Sat night and Sun night, so on Mon morning at work o'clock there are still X hours left to run of Saturday's jab)