Amity Island
Well-Known Member
- Relationship to Diabetes
- Type 1
A brief note on some patients who are allergic to insulin.
Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes mellitus (DM), and characterized by hyperglycemia, metabolic acidosis, and increased total ketone body concentrations. The main mechanism of DKA is a lack of insulin in the body. It has been reported that some immunological response is associated with insulin therapy. Herein, we report a case of serious DKA, which was induced by insulin allergy and anti-insulin antibody. This case clearly indicates that DKA can be induced by insulin allergy and anti-insulin antibodies in subjects with T2DM treated with insulin. Moreover, we should know that since required insulin dose may be very high under severe insulin resistance and serious DKA in such cases, we should increase insulin dose appropriately while monitoring pH, BE and other factors.
Diabetic ketoacidosis (DKA) is one of the most serious acute metabolic complications of diabetes mellitus (DM), and characterized by hyperglycemia, metabolic acidosis, and increased total ketone body concentrations. The main mechanism of DKA is a lack of insulin in the body. It has been reported that some immunological response is associated with insulin therapy. Herein, we report a case of serious DKA, which was induced by insulin allergy and anti-insulin antibody. This case clearly indicates that DKA can be induced by insulin allergy and anti-insulin antibodies in subjects with T2DM treated with insulin. Moreover, we should know that since required insulin dose may be very high under severe insulin resistance and serious DKA in such cases, we should increase insulin dose appropriately while monitoring pH, BE and other factors.