Inhaled insulin

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As @Inka said, Afrezza has not been licensed in the UK.
I have a friend in the US who uses it as a “top up” as it works very fast.
 
The subject cropped up last year, and I can’t find anything updated from NICE since it was assessed as ’too expensive’, and not recommended.

I posted this at the time:

Unfortunately I have a slightly uneasy feeling about Afrezza.

As far as I am aware it is still not licensed for use in the UK and not available on prescription here. NICE were considering a technology appraisal in 2014, but I‘m not sure if that ever happened

https://www.nice.org.uk/media/default/About/what-we-do/NICE-guidance/NICE-technology-appraisals/Proposed-appraisals-no-wave/Human-insulin-afrezza-draft-scope.pdf

Afrezza has had a troubled history, and was dropped by Sanofi who had taken it on to develop it, but didn’t see a future in it.

Some of the posting and social media review (plus associated forum activity) around it seems very hard sell and almost as if those involved are part of some kind of pyramid scheme. I have no evidence of that - just observing the behaviours and social media interactions I’ve seen around it.

EDIT: Found this which was a NICE TA possibly earlier (due to be reviewed in 2009). Inhaled human insulin

1.1 Inhaled insulin is not recommended for the routine treatment of people with type 1 or type 2 diabetes mellitus
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https://www.nice.org.uk/guidance/ta113/documents/diabetes-type-1-and-2-inhaled-insulin-final-appraisal-determination2
 
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I have a vague recollection that some folk with D Insipidus, used to use it, but not D Mellitus.
 
trophywench said:
I have a vague recollection that some folk with D Insipidus, used to use it, but not D Mellitus.
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Diabetes Insipidus isn’t to do with blood glucose and insulin. I think you might be thinking of a different drug that happens to be in a nasal spray form? Desmopressin or similar?
 
Was something someone mentioned about 35-40 years ago - his wife had DI and controlled it with inhaled insulin, so he said. Bloke we talked to for approx 10 minutes in a hotel in Devon!
 
A misunderstanding, I’d think. Desmopressin is a nasal spray. I don’t think inhaled insulin was even invented all those years ago.
 
I think it had been invented cos I'd definitely heard of it at the time, presumably seen it mentioned in Balance as I certainly had no personal access to the internet at that time.
 
20 years ago they were talking about hoping to develop a way to give it through the skin without needles (kind of blasting it as a very fine powder)
 
trophywench said:
I think it had been invented cos I'd definitely heard of it at the time, presumably seen it mentioned in Balance as I certainly had no personal access to the internet at that time.
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It might have been talked about as a possibility but it wasn’t approved until the 2000s:

https://en.m.wikipedia.org/wiki/Inhalable_insulin

But the main thing is that Diabetes Insipidus doesn’t need insulin anyway, inhaled or injected. People with DI have no problem with their blood sugar. They just can’t stop drinking/peeing due to a problem with the way their body regulates their fluid balance.

https://www.pituitary.org.uk/information/pituitary-conditions/diabetes-insipidus/

.
 
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