Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Our gut microbiomes -- the bacteria that live in our digestive tract -- play major roles in our health. Scientists around the world are studying therapies that manipulate the microbiome, including probiotics (such as live bacterial cultures in yogurt), prebiotics (edible fibers meant to promote beneficial bacteria), antibiotics and transplants of microbes from healthy people.
Joslin Diabetes Center investigators now are shedding light on how the success of such microbiome treatments may be affected by genetics of the individual or animal being treated.
In work published online by the Journal of Clinical Investigation, a team of Joslin researchers reported on experiments among three genetically different strains of mice (two closely related and one more distant). They discovered that giving the mice antibiotics produced very different effects on their gut microbiomes, as well as on their insulin sensitivity, tissue inflammation and related metabolic functions such as blood glucose, depending on the genetic background of the mouse.
https://www.sciencedaily.com/releases/2016/11/161107160749.htm
Joslin Diabetes Center investigators now are shedding light on how the success of such microbiome treatments may be affected by genetics of the individual or animal being treated.
In work published online by the Journal of Clinical Investigation, a team of Joslin researchers reported on experiments among three genetically different strains of mice (two closely related and one more distant). They discovered that giving the mice antibiotics produced very different effects on their gut microbiomes, as well as on their insulin sensitivity, tissue inflammation and related metabolic functions such as blood glucose, depending on the genetic background of the mouse.
https://www.sciencedaily.com/releases/2016/11/161107160749.htm
