I only saw the second half of the prog, but like you two I found it interesting though it left me with far more questions than answers...
For example they focussed on VO2max as a 'key indicator' of all form mortality and seemed to stop measuring any other markers of cardio-vascular health or otherwise. So when they were saying that effectively he was genetically unable to get any fitter they were presumably only talking about his VO2max, not his resting heart rate, nor the time taked for heart rate to return to normal after exertion, nor any other of the fitness markers.
I also don't really follow the logic of focussing on one factor like that. Here we have a whole load of people, living varied lives. Here is one measurable thing amid millions of other measurable things. The people with a higher (or lower) version of this particular 'thing' live longer. Therefore if we find a way of affecting the 'thing' level in these other people living completely different lives in completely different bodies they will live longer too.
Seems a bit like noticing that it always seems to rain when you are wearing blue socks, and deducing that your sock choice controls the weather.
And as Helen says, he was actively trying other strategies at the same time...
It's an interesting idea, and they were clear that it won't work for everyone, but then when they were talking about it 'not working' they kept interchanging whether it was HIT or exercise in general that would not work for some people.
The most encouraging man/presentation I thought was the guy talking about NEAT. Just generally gently doing more pottering about in order to keep the bodies engine functioning well.