I’ve been searching for a while for what causes insulin resistance but not had much luck. Just this last weekend I found some research.
Background. Five years before being DX’D as T2D in Nov 2004, I was DX’d with gout. Gout is caused by high levels of serum uric acid. Uric acid is produced by the liver by processing ingested purines and then cleared out of the body - through peeing. If uric acid in the blood gets too high it crystallizes in the joint - more often the big toe but others too.
Uric acid can also be high without causing gout. I had been in this position a few years ago. I now take 100mg of allopurinol each morning. There is a strong connection between diabetes and gout:
https://www.diabetes.co.uk/conditions/gout-and-diabetes.html
I did a search of “uric acid insulin resistance” and got many hits of research material stating URIC ACID CAUSES INSULIN RESISTANCE! Examples…
https://www.frontiersin.org/articles/10.3389/fendo.2018.00098/full
https://www.nature.com/articles/s41598-018-29955-w
Highest levels of purines are found in meat products and some veggies. Purines come from foods we eat…
https://elevatehealthaz.com/wp-content/Purine Table.pdf
Another source of purines is fructose (bad stuff in large quantities)
My own testing has shown that when I stopped eating meat two years ago, my blood glucose levels and HbA1c, went down. When I ate Xmas cake (raisins, current, nuts and sugar free), my HbA1c went up. It’s now gone back down again.
It may be worthwhile concentrating harder on treating the uric acid levels - I have a uric acid level test with he HbA1c test every 3 months. I need to have a conversation with my GP about this.
Interestingly, a treatment for gout, colchicine, is being tested (clinical trials) as a treatment for COVID-19 here in Canada.
Stay safe everybody.
Background. Five years before being DX’D as T2D in Nov 2004, I was DX’d with gout. Gout is caused by high levels of serum uric acid. Uric acid is produced by the liver by processing ingested purines and then cleared out of the body - through peeing. If uric acid in the blood gets too high it crystallizes in the joint - more often the big toe but others too.
Uric acid can also be high without causing gout. I had been in this position a few years ago. I now take 100mg of allopurinol each morning. There is a strong connection between diabetes and gout:
https://www.diabetes.co.uk/conditions/gout-and-diabetes.html
I did a search of “uric acid insulin resistance” and got many hits of research material stating URIC ACID CAUSES INSULIN RESISTANCE! Examples…
https://www.frontiersin.org/articles/10.3389/fendo.2018.00098/full
https://www.nature.com/articles/s41598-018-29955-w
Highest levels of purines are found in meat products and some veggies. Purines come from foods we eat…
https://elevatehealthaz.com/wp-content/Purine Table.pdf
Another source of purines is fructose (bad stuff in large quantities)
My own testing has shown that when I stopped eating meat two years ago, my blood glucose levels and HbA1c, went down. When I ate Xmas cake (raisins, current, nuts and sugar free), my HbA1c went up. It’s now gone back down again.
It may be worthwhile concentrating harder on treating the uric acid levels - I have a uric acid level test with he HbA1c test every 3 months. I need to have a conversation with my GP about this.
Interestingly, a treatment for gout, colchicine, is being tested (clinical trials) as a treatment for COVID-19 here in Canada.
Stay safe everybody.
