Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Why do orally-administered drugs for diabetes work for some people but not others?
According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.
In a review of more than 100 current published studies in humans and rodents, the School of Medicine team examined how gut bacteria either enhanced or inhibited a drug's effectiveness. The review is published in the Dec.11 edition of the journal EBioMedicine.
"For example, certain drugs work fine when given intravenously and go directly to the circulation, but when they are taken orally and pass through the gut, they don't work," said Hariom Yadav, Ph.D., assistant professor of molecular medicine at the School of Medicine, a part of Wake Forest Baptist Medical Center.
https://www.sciencedaily.com/releases/2018/12/181211122445.htm
According to researchers at Wake Forest School of Medicine, bacteria that make up the gut microbiome may be the culprit.
In a review of more than 100 current published studies in humans and rodents, the School of Medicine team examined how gut bacteria either enhanced or inhibited a drug's effectiveness. The review is published in the Dec.11 edition of the journal EBioMedicine.
"For example, certain drugs work fine when given intravenously and go directly to the circulation, but when they are taken orally and pass through the gut, they don't work," said Hariom Yadav, Ph.D., assistant professor of molecular medicine at the School of Medicine, a part of Wake Forest Baptist Medical Center.
https://www.sciencedaily.com/releases/2018/12/181211122445.htm
