Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Italian investigators have found evidence of worsening glucose tolerance in highly treatment-experienced HIV-positive patients treated with nucleoside-sparing regimens. The small study, which is published in the online edition of AIDS, monitored the glucose metabolism of 39 patients over three years.
?The drugs included in these regimens have not been specifically associated with worsening of glucose metabolism,? note the authors.
The patients were treated with two alternative combinations: raltegravir (Isentress), etravirine (Intelence) plus maraviroc (Celsentri); or raltegravir, etravirine with ritonavir-boosted darunavir (Prezista). A total of fifteenth patients (39%) were treated with the maraviroc-containing regimen and 61% received the darunavir/ritonavir-based therapy. All were highly treatment experienced and were switched to these regimens because of virological failure.
http://www.aidsmap.com/Glucose-meta...ed-taking-NRTI-sparing-regimens/page/2471179/
?The drugs included in these regimens have not been specifically associated with worsening of glucose metabolism,? note the authors.
The patients were treated with two alternative combinations: raltegravir (Isentress), etravirine (Intelence) plus maraviroc (Celsentri); or raltegravir, etravirine with ritonavir-boosted darunavir (Prezista). A total of fifteenth patients (39%) were treated with the maraviroc-containing regimen and 61% received the darunavir/ritonavir-based therapy. All were highly treatment experienced and were switched to these regimens because of virological failure.
http://www.aidsmap.com/Glucose-meta...ed-taking-NRTI-sparing-regimens/page/2471179/