Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs), used for diabetes or obesity, are associated with a significantly lower quality of bowel preparation and a greater need for repeat colonoscopy, new research suggests.
"We began observing inadequate bowel preparation in our patients undergoing colonoscopy who were on GLP-1 RAs, which raised questions, especially given the association between these medications and delays in intestinal transit," study investigator Eric. J. Vargas, MD of the Mayo Clinic in Rochester, Minnesota, told Medscape Medical News. The team decided to investigate.
The "most surprising finding" was the "notably higher rate of inadequate bowel preparation, which necessitates a repeat colonoscopy within 12 months to ensure adequate screening and surveillance for colorectal cancers," he said. "Specifically, for every 14 patients treated with GLP-1 RAs, one patient would require a repeat colonoscopy due to suboptimal preparation."
"We began observing inadequate bowel preparation in our patients undergoing colonoscopy who were on GLP-1 RAs, which raised questions, especially given the association between these medications and delays in intestinal transit," study investigator Eric. J. Vargas, MD of the Mayo Clinic in Rochester, Minnesota, told Medscape Medical News. The team decided to investigate.
The "most surprising finding" was the "notably higher rate of inadequate bowel preparation, which necessitates a repeat colonoscopy within 12 months to ensure adequate screening and surveillance for colorectal cancers," he said. "Specifically, for every 14 patients treated with GLP-1 RAs, one patient would require a repeat colonoscopy due to suboptimal preparation."
GLP-1 RAs Tied to Suboptimal Bowel Prep, Repeat Colonoscopy
For every 14 patients on a GLP-1 RA undergoing colonoscopy, one patient would require a repeat procedure owing to inadequate prep, results indicate.
www.medscape.com