Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
In people aged 20-40 years who have been diagnosed with diabetes, routine genetic screening for maturity-onset diabetes of youth could result in more targeted treatment. But the costs of genetic testing need to come down before routine screening becomes cost effective.
Using a simulation model of type 2 diabetes complications that accounted for the natural history of disease by genetic subtypes, investigators found that genetic screening added 0.01 quality-adjusted life-years (19.22 vs. 19.21 with no screening) at an increased total cost of $1,727 ($41,033 vs. $39,306). The incremental cost-effectiveness ratio (or cost per quality-adjusted life-years) was $143,409.
Genetic testing becomes more cost effective as the cost of the test decreases. If the prevalence of maturity-onset diabetes of youth (MODY) in the screened population is 5% or greater, and the cost of the test drops to less than $1,000, then the incremental cost-effectiveness ratio would go to $50,000, which is considered to be the conventional cost-effectiveness threshold. If the test cost falls to $200, then the screening policy would be cost saving, presuming that the MODY prevalence in the screened population was 20% or higher, said Dr. Rochelle N. Naylor, a pediatric endocrinology fellow at the University of Chicago?s National Center for Monogenic Diabetes.
http://www.familypracticenews.com/n...f-youth/7dd62524ba699d696273d951ccb9c265.html
Using a simulation model of type 2 diabetes complications that accounted for the natural history of disease by genetic subtypes, investigators found that genetic screening added 0.01 quality-adjusted life-years (19.22 vs. 19.21 with no screening) at an increased total cost of $1,727 ($41,033 vs. $39,306). The incremental cost-effectiveness ratio (or cost per quality-adjusted life-years) was $143,409.
Genetic testing becomes more cost effective as the cost of the test decreases. If the prevalence of maturity-onset diabetes of youth (MODY) in the screened population is 5% or greater, and the cost of the test drops to less than $1,000, then the incremental cost-effectiveness ratio would go to $50,000, which is considered to be the conventional cost-effectiveness threshold. If the test cost falls to $200, then the screening policy would be cost saving, presuming that the MODY prevalence in the screened population was 20% or higher, said Dr. Rochelle N. Naylor, a pediatric endocrinology fellow at the University of Chicago?s National Center for Monogenic Diabetes.
http://www.familypracticenews.com/n...f-youth/7dd62524ba699d696273d951ccb9c265.html