Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
A genetic variant may help explain why some patients experience muscle discomfort and dysfunction while taking the cholesterol-lowering medications.
Using a novel approach, researchers have discovered a genetic variant that may contribute to the muscle pain and weakness experienced by some statin users, according to a study published in Nature today (August 28). Under statin-treated conditions, the variant affects expression of the gene for glycine amidinotransferase (GATM), which controls the synthesis rate of creatine, a molecule muscles use for energy.
?The authors used a really unique approach for trying to understand why some people might respond differently [to statins],? said Deepak Voora, a physician-scientist studying pharmacogenetics at Duke University, who was not involved in the research. ?That approach will have implications for studying other drugs.?
http://www.the-scientist.com/?articles.view/articleNo/37272/title/Gene-a-Pain-for-Statin-Users/
Using a novel approach, researchers have discovered a genetic variant that may contribute to the muscle pain and weakness experienced by some statin users, according to a study published in Nature today (August 28). Under statin-treated conditions, the variant affects expression of the gene for glycine amidinotransferase (GATM), which controls the synthesis rate of creatine, a molecule muscles use for energy.
?The authors used a really unique approach for trying to understand why some people might respond differently [to statins],? said Deepak Voora, a physician-scientist studying pharmacogenetics at Duke University, who was not involved in the research. ?That approach will have implications for studying other drugs.?
http://www.the-scientist.com/?articles.view/articleNo/37272/title/Gene-a-Pain-for-Statin-Users/