Fructose Intake Linked to Liver Damage

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Northerner

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Relationship to Diabetes
Type 1
In obese patients with diabetes, a high intake of fructose ? a sugar widely used in soft drinks and other foods ? is associated with impairment in cellular energy balance that may play a role in liver disease, researchers said.

A small pilot study also suggested that elevated uric acid levels in response to a fructose challenge might be a marker for energy depletion, according to Manal Abdelmalek, MD, of Duke University Medical Center, and colleagues.

The findings suggest that energy depletion in the liver might be a factor in the development and progression of nonalcoholic fatty liver disease (NAFLD), Abdelmalek and colleagues reported in the Sept. issue of Hepatology.

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