FDA Approves New Ready-to-Inject Glucagon Product

[Northerner]

The US Food and Drug Administration (FDA) has approved dasiglucagon (Zegalogue 0.6 mg/0.6 mL, Zealand Pharma) autoinjector and prefilled syringe for the treatment of severe hypoglycemia in people with diabetes aged 6 and older.

The product has a shelf-life of 36 months at refrigerated temperatures and is stable for up to 12 months at room temperature.

"This approval will help enable appropriate children and adults with diabetes to be able to address sudden and severe hypoglycemia, which can quickly progress from a mild event to an emergency," said Jeremy Pettus, MD, assistant professor of medicine at the University of California San Diego, in a company statement.

The approval marks the latest step in the development of newer glucagon formulations that are easier to use in hypoglycemic emergencies than the traditional formulation that requires several steps for reconstitution.

FDA Approves New Ready-to-Inject Glucagon Product

Dasiglucagon is the third of newer-generation glucagon products that don't require multistep reconstitution in emergency hypoglycemic situations.

www.medscape.com

 

[mikeyB]

That’s not really interesting for me. I’ve never possessed, used, or been given Glucagon. Now that I use the Libre it makes it a complete irrelevance.

The trouble with Gucagon is that empties the last redoubt of your body’s defences against hypoglycaemia, which have to be refilled. In the time it takes to sort out a glucagon injection, I could have eaten a whole pack of Dextro tablets.

That’s just me, mind. I don’t doubt there are many folk who would welcome this.

 

[Amity Island]

That’s not really interesting for me. I’ve never possessed, used, or been given Glucagon. Now that I use the Libre it makes it a complete irrelevance.

Especially with libre 2 alarms.

But for all those still not able to access the libre, a welcome development, especially for those without hypo awareness.

 

[Robin]

I suppose people who carry one will be subject to the Russian Roulette of being found unconscious, and having a 50/50 chance of whether some well meaning passer by injects them with the Glucagon or their insulin.

 

[Amity Island]

I suppose people who carry one will be subject to the Russian Roulette of being found unconscious, and having a 50/50 chance of whether some well meaning passer by injects them with the Glucagon or their insulin.

Interesting point @Robin It does say keep in fridge, which seems to hint at home use only?

 

[Amity Island]

I suppose people who carry one will be subject to the Russian Roulette of being found unconscious, and having a 50/50 chance of whether some well meaning passer by injects them with the Glucagon or their insulin.

That raises a question I have often pondered. If a confirmed diabetic is found partly/unconscious, does one give them some glucose or not. E.g are they hyper or hypo? Not sure what first aiders are taught?

 

[nonethewiser]

Kit is to be used by family friends trained to use device not for strangers on street, most folk would just phone for ambulance.

 

[Robin]

That raises a question I have often pondered. If a confirmed diabetic is found partly/unconscious, does one give them some glucose or not. E.g are they hyper or hypo? Not sure what first aiders are taught?

From what I've read in the past, the advice is, give them glucose and call an ambulance. If they’re hypo it may save their life, it they’re hyper, a little bit more glucose isn’t going to make much difference.
One would hope that a passer-by would just call an ambulance, @nonethewiser, I was just musing about a hypothetical 'do gooder' who has watched Casualty and thinks they know what to do!

 

[trophywench]

.... and not have the fun of the projectile vomit when coming round? Some of you just don't know what you've been missing!!!

It has saved my life and sanity more than once.

 

[trophywench]

Pete would have called 999 of course - as my first husband had to, before him, a few times. Then I'd wake up next morning wondering why Radio 2 was on instead of Radio 1 and hang on, we haven't got a pegboard ceiling in our house, cos I was in Kidderminster hospital where they'd sorted me whilst I was out of it and would ask me if I'd like a nice cup of tea or a bedpan (both please, bedpan first if you would?) and then they'd ring my husband to come and fetch me. Sorry, but could they ask him to bring me some shoes please? Thanks for sorting me out, again. No, it's no trouble.......

 

[everydayupsanddowns]

This is interesting that a whole new product has been approved already.

I gather the stability of soluble glucagon has been problematic for a while (there are dual-hormone pumps being developed, and this has been a stumbling block.

The product I was expecting to arrive on the market was the inhalable version, which was in advanced trials a few years back. Not heard anything about that for a while tho