Some research indicates the body handles food in the morning better than the evening - one study found 17% higher glucose levels in the evening than the morning, same person/same meal. Circadian rhythms!
I haven't done any research on this but it wouldn't surprise me if another paper suggested the opposite - a different person with different circadian rhythms.
Just found
the article (abstract) again,
full text here, published 2015, abstract:
"Glucose tolerance is lower in the evening and at night than in the morning. However, the relative contribution of the circadian system vs. the behavioral cycle (including the sleep/wake and fasting/feeding cycles) is unclear. Furthermore, although shift work is a diabetes risk factor, the separate impact on glucose tolerance of the behavioral cycle, circadian phase, and circadian disruption (i.e., misalignment between the central circadian pacemaker and the behavioral cycle) has not been systematically studied.
Here we show--by using two 8-d laboratory protocols--in healthy adults that the circadian system and circadian misalignment have distinct influences on glucose tolerance, both separate from the behavioral cycle. First,
postprandial glucose was 17% higher (i.e., lower glucose tolerance) in the biological evening (8:00 PM) than morning (8:00 AM; i.e., a circadian phase effect), independent of the behavioral cycle effect. Second, circadian misalignment itself (12-h behavioral cycle inversion) increased postprandial glucose by 6%. Third,
these variations in glucose tolerance appeared to be explained, at least in part, by different mechanisms:
during the biological evening by decreased pancreatic β-cell function (27% lower early-phase insulin) and during circadian misalignment presumably by decreased insulin sensitivity (elevated postprandial glucose despite 14% higher late-phase insulin) without change in early-phase insulin. We explored possible contributing factors, including changes in polysomnographic sleep and 24-h hormonal profiles.
We demonstrate that the circadian system importantly contributes to the reduced glucose tolerance observed in the evening compared with the morning. Separately, circadian misalignment reduces glucose tolerance, providing a mechanism to help explain the increased diabetes risk in shift workers."
Participants
"
Fourteen healthy nonsmoking, drug- and medication-free (except for oral contraceptive agents) adults completed this study [mean age ± SD (range), 28 ± 9 y (20–49 y); BMI, 25.4 ± 2.6 kg/m2 (21–29.5 kg/m2); eight men]. Health status was determined by physical examination, standard laboratory tests, and psychiatric assessment."
Since 2015 there has been quite a lot of research into 'early Time Restricted Eating' (eTRE), such as
this which has some good graphics comparing 'metabolic levels'.