• Please Remember: Members are only permitted to share their own experiences. Members are not qualified to give medical advice. Additionally, everyone manages their health differently. Please be respectful of other people's opinions about their own diabetes management.
  • We seem to be having technical difficulties with new user accounts. If you are trying to register please check your Spam or Junk folder for your confirmation email. If you still haven't received a confirmation email, please reach out to our support inbox: support.forum@diabetes.org.uk

Evidence for rebooting beta cells with weight loss in T2D

Status
This thread is now closed. Please contact Anna DUK, Ieva DUK or everydayupsanddowns if you would like it re-opened.

Eddy Edson

Well-Known Member
Relationship to Diabetes
In remission from Type 2
A study offshoot from the DiRECT 2-year follow up, supporting the hypothesis that clearing fat from the pancreas can allow beta cells to reboot, in T2D.

https://care.diabetesjournals.org/content/early/2020/01/22/dc19-0371

RESULTS During remission, median (interquartile range) maximal rate of insulin secretion increased from 581 (480–811) pmol/min/m2 at baseline to 736 (542–998) pmol/min/m2 at 5 months, 942 (565–1,240) pmol/min/m2 at 12 months (P = 0.028 from baseline), and 936 (635–1,435) pmol/min/m2 at 24 months (P = 0.023 from baseline; n = 20 of 39 of those initially in remission). This was comparable to the NDC [nondiabetic control] group (1,016 [857–1,507] pmol/min/m2) by 12 (P = 0.064) and 24 (P = 0.244) months. Median first-phase insulin response increased from baseline to 5 months (42 [4–67] to 107 [59–163] pmol/min/m2; P < 0.0001) and then remained stable at 12 and 24 months (110 [59–201] and 125 [65–166] pmol/min/m2, respectively; P < 0.0001 vs. baseline) but lower than that of the NDC group (250 [226–429] pmol/min/m2; P < 0.0001).

CONCLUSIONS A gradual increase in assessed functional β-cell capacity occurred after weight loss, becoming similar to NDC participants by 12 months. This was unchanged at 2 years with continuing remission of type 2 diabetes.
 
It’s nothing to do with a “reboot” of the beta cells, it’s just clearing the way for the insulin hormone to escape. Common sense. Like taking the wrapping off a pack of custard creams.
 
It’s nothing to do with a “reboot” of the beta cells, it’s just clearing the way for the insulin hormone to escape. Common sense. Like taking the wrapping off a pack of custard creams.

Well, the papers refer to it as loss & regain of beta cell "specialised function".

It appears to enter a survival mode in which its specialised functions are shut down. Removal of the fat allows re-expression of the insulin gene and resumption of acute glucose-mediated insulin secretion

I'm sticking with "re-boot" 🙂
 
If there weren't so many numbers involved I would feel less intimidated by diabetes!😉
 
Status
This thread is now closed. Please contact Anna DUK, Ieva DUK or everydayupsanddowns if you would like it re-opened.
Back
Top