Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Insulin resistance (IR) is associated with increased fibroblast growth factor-23 levels in chronic kidney disease (CKD) patients, suggesting a link between IR and renal phosphorus homeostasis, according to a cross-sectional study.
Presented at a poster session at the 3rd International Congress on Abdominal Obesity, the analysis of 72 patients with stage 3-5 CKD also showed that IR is associated with a greater severity of coronary artery calcification (CAC).
Patients with type 2 diabetes who were treated with insulin were excluded from the study. Investigators looked at fibroblast growth factor-23 (FGF-23) as a biomarker to assess disrupted renal phosphorus homeostasis. IR was assessed by the homeostasis model assessment of IR (HOMA-IR). The mean age of patients in the study was 64, the mean estimated glomerular filtration rate was 25.9 mL/min/1,73m2, the median HOMA-IR was 2.19, and the median CAC was 112 Agatston units.
http://www.renalandurologynews.com/elevated-fgf-23-linked-to-insulin-resistance/article/250510/
Presented at a poster session at the 3rd International Congress on Abdominal Obesity, the analysis of 72 patients with stage 3-5 CKD also showed that IR is associated with a greater severity of coronary artery calcification (CAC).
Patients with type 2 diabetes who were treated with insulin were excluded from the study. Investigators looked at fibroblast growth factor-23 (FGF-23) as a biomarker to assess disrupted renal phosphorus homeostasis. IR was assessed by the homeostasis model assessment of IR (HOMA-IR). The mean age of patients in the study was 64, the mean estimated glomerular filtration rate was 25.9 mL/min/1,73m2, the median HOMA-IR was 2.19, and the median CAC was 112 Agatston units.
http://www.renalandurologynews.com/elevated-fgf-23-linked-to-insulin-resistance/article/250510/