Disorder-specific effects of polymorphisms at opposing ends of the Insulin DE gene

[Northerner]

Insulin-degrading enzyme (IDE) is the ubiquitously expressed enzyme responsible for insulin and amyloid beta (Abeta) degradation. IDE gene is located on chromosome region 10q23-q25 and exhibits a well-replicated peak of linkage with Type 2 diabetes mellitus (T2DM).

Several genetic association studies examined IDE gene as a susceptibility gene for Alzheimer's disease (AD), however with controversial results.

http://7thspace.com/headlines/40037...ds_of_the_insulin_degrading_enzyme_gene_.html

Eh? 😱 😉