Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Genetic variation plays a large part in explaining why metformin is much better at lowering blood glucose in some people with diabetes than others, a UK study suggests.
Kaixin Zhou and colleagues from the University of Dundee used data from 3,736 individuals to look for gene variants linked to glycaemic response to metformin.
The researchers looked at the reduction in HbA1c achieved with 18 months of beginning metformin treatment.
They found that 36% of the difference across individuals in glycaemic response to metformin could be explained by inherited genetic variation. This suggests that response to metformin is more strongly linked to genetic factors than individuals' height or the age at which they develop diabetes.
Mr Zhou presented the findings at the 2012 meeting of the European Association for the Study of Diabetes in Berlin, Germany on 2 October 2012.
http://www.gponline.com/News/articl...atment-response-determined-genetic-variation/
Kaixin Zhou and colleagues from the University of Dundee used data from 3,736 individuals to look for gene variants linked to glycaemic response to metformin.
The researchers looked at the reduction in HbA1c achieved with 18 months of beginning metformin treatment.
They found that 36% of the difference across individuals in glycaemic response to metformin could be explained by inherited genetic variation. This suggests that response to metformin is more strongly linked to genetic factors than individuals' height or the age at which they develop diabetes.
Mr Zhou presented the findings at the 2012 meeting of the European Association for the Study of Diabetes in Berlin, Germany on 2 October 2012.
http://www.gponline.com/News/articl...atment-response-determined-genetic-variation/