Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
New research from the University of Cincinnati (UC) points to the naturally produced protein apolipoprotein A-IV (apoA-IV) as a potential target for a new diabetes therapeutic.
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has published research on the ability of apoA-IV to reduce blood sugar levels and enhance insulin secretion.
The results appear the week of May 21, 2012, in the online early edition of Proceedings of the National Academy of Sciences.
ApoA-IV is secreted by the small intestine in response to fat absorption. Previous studies have shown apoA-IV to be elevated in humans following gastric bypass?coinciding with improvement in symptoms for diabetes.
The Tso team found that mice deficient in apoA-IV had impaired glucose tolerance (insulin was not secreted to move glucose from the blood stream). These mice also developed diabetes when continuously fed a high-fat diet. When injected with apoA-IV, these same mice showed improved insulin response to glucose, despite a diet high in fat.
Tso's team also tested the response to injected apoA-IV in diabetic mice and found it reduced glucose levels among that group as well.
http://www.eurekalert.org/pub_releases/2012-05/uoca-ddt051812.php
Patrick Tso, PhD, professor in the UC Department of Pathology and Laboratory Medicine, has published research on the ability of apoA-IV to reduce blood sugar levels and enhance insulin secretion.
The results appear the week of May 21, 2012, in the online early edition of Proceedings of the National Academy of Sciences.
ApoA-IV is secreted by the small intestine in response to fat absorption. Previous studies have shown apoA-IV to be elevated in humans following gastric bypass?coinciding with improvement in symptoms for diabetes.
The Tso team found that mice deficient in apoA-IV had impaired glucose tolerance (insulin was not secreted to move glucose from the blood stream). These mice also developed diabetes when continuously fed a high-fat diet. When injected with apoA-IV, these same mice showed improved insulin response to glucose, despite a diet high in fat.
Tso's team also tested the response to injected apoA-IV in diabetic mice and found it reduced glucose levels among that group as well.
http://www.eurekalert.org/pub_releases/2012-05/uoca-ddt051812.php