Diabetes: A new insight of the protective role of estrogens

[Northerner]

Epidemiological data indicate an explosion of type 2 diabetes cases for women after menopause. What is responsible for that? The surprisingly protective role of estrogens, highlighted by the fact that a woman undergoing hormone replacement therapy has up to 35% less risks of developing type 2 diabetes than a woman without treatment. By elucidating how estrogen affects two of the hormones involved in glucose homeostasis, glucagon and GLP1, researchers at the University of Geneva (UNIGE), Switzerland, and at the Geneva University Hospitals (HUG) prove the value of estrogen supplementation from the onset of menopause. This research, published in JCI Insight, also shows that only one of the three estrogen receptors seems to be involved in this mechanism. This could ultimately provide much more targeted therapies with a specific molecule that would prevent patients the sometimes embarrassing side effects when treated with a too powerful hormonal therapy.

https://www.sciencedaily.com/releases/2018/04/180405093249.htm

 

[mikeyB]

This could result in a lot of T2 men identifying as women

 

[trophywench]

Grrrrr - tell the NHS - I had to stop HRT in my 50s because the doc reckoned I was too old to keep taking it so refused to prescribe any more. And that was that. Briefly it led to completely wrecking both of us's sex life - and my OH still very much resents that which is not easy to live with when I resent it too.

I have always assumed that all ladies in their late 50s would have to stop HRT - but don't know if it is true or not.

 

[Nayshiftin]

They have never given me any . Used my late sisters breast cancer saying that I was not a candidate too risky . But as I’ve only one ovary and pcos and had things gynae in the past . I think this might be the flushed even years on . Supposed to have started this at 36 and now still at 57 . I think the headaches and flushes must be something to do with it. Maybe a GPl 1 might be the way to go .

 

[Leadinglights]

They have never given me any . Used my late sisters breast cancer saying that I was not a candidate too risky . But as I’ve only one ovary and pcos and had things gynae in the past . I think this might be the flushed even years on . Supposed to have started this at 36 and now still at 57 . I think the headaches and flushes must be something to do with it. Maybe a GPl 1 might be the way to go .

I had a total hysterectomy at age 32 and I was told that I would experience menopause symptoms pretty well immediately after. But I never did and haven't anytime since. I could never quite work that out.

 

[Nayshiftin]

Bless you , I’d say perhaps you are better not having the symptoms of the menopause. However it must have been hard to have had a total hysterectomy so young . I often wish they had for me but I had an ovary wedged at 15 and then when my daughter was born a three hour op to remove an ovary and cysts . . Have had two children do I am grateful for them .

 

[rebrascora]

I've been on HRT patches for a couple of years now and I have to do a custom request for a repeat prescription. I worry each time that they will say no more. I manage on just half the dose at one patch a week instead of 2 and they really are lifechanging. No apparent side effects but the relief from debilitating menopausal symptoms is just such a massive relief!

Really interesting that it could also protect from Type 2 diabetes.

 

[Leadinglights]

Bless you , I’d say perhaps you are better not having the symptoms of the menopause. However it must have been hard to have had a total hysterectomy so young . I often wish they had for me but I had an ovary wedged at 15 and then when my daughter was born a three hour op to remove an ovary and cysts . . Have had two children do I am grateful for them .

I had a precancerous ovarian cyst the size of a grapefruit and they said the chance that it would occur in the other ovary was high hence whipping everything out. I don't thing they would have done something so radical now, that was 40 years ago. I already had 2 children.

 

[Nayshiftin]

No I think there has been evidence not too but yes still a lot have hysterectomies.