Creating ?death-defying? insulin-producing islets for transplantation

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Northerner

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Type 1
Australian scientists have identified one way of making a frustratingly tricky transplant ? of insulin-producing ?islets of Langerhans? into patients with Type 1 diabetes ? more successful.

A Sydney team, part of the Commonwealth-funded Australian Islet Transplant Consortium formed in 2006, has found that islets are severely handicapped from the outset. Before they ever reach their mark, they are full of inflammatory molecules, much like stressed or damaged tissue.

Associate Professor Shane Grey and Drs Mark Cowley and Anita Weinberg, from Sydney?s Garvan Institute of Medical Research, detailed the ?molecular signatures? of islets that were transplanted into 15 recipients as part of a 5-year clinical trial spanning Sydney, Melbourne and Adelaide. Their findings, published online in Cell Transplantation, used the latest sequencing technologies to identify inflammatory signatures.

http://www.healthcanal.com/metaboli...lin-producing-islets-for-transplantation.html
 
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