Circadian clock gene Rev-erb linked to dawn phenomenon in type 2 diabetes

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Northerner

Northerner

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Researchers at Baylor College of Medicine, Shandong University in China and other institutions may have found an explanation for dawn phenomenon, an abnormal increase of blood sugar only in the morning, observed in many patients with type 2 diabetes. They report in the journal Nature that mice lacking the circadian clock gene called Rev-erb in the brain show characteristics similar to those of dawn phenomenon.

The researchers then looked at Rev-erb gene expression in patients with type 2 diabetes comparing a group with dawn phenomenon to a group without it and found that the gene's expression followed a different temporal pattern between these two groups. The findings support the idea that an altered daily rhythm of expression of the Rev-erb gene may underlie dawn phenomenon. Future investigations may lead to therapies.

www.sciencedaily.com

Circadian clock gene Rev-erb linked to dawn phenomenon in type 2 diabetes

Researchers found that mice lacking the circadian clock gene called Rev-erb in the brain show characteristics similar to those of human dawn phenomenon in type 2 diabetes.
www.sciencedaily.com
 
I think they may be barking up the wrong tree here. I know mice don’t bark, but you know what I mean. Or they are reinventing the wheel.

We all have a circadian rhythm, but it is highly complex and can be modified. All nocturnal animals, such as bats, have one. It’s one of the most fundamental expressed genes in life on Earth. Hamsters tend to be nocturnal, which is why they make such bloody awful pets. Kids try to keep them awake, then they die. Mice are largely nocturnal too.

In all animals, when they wake, the BG rises to cope with the stresses of the day finding food, whether they are nocturnal or not. The thing is, the circadian rhythm is not the same as the sleep/wake cycle. The circadian rhythm just fits it all into approximately 24 hours. The sleep/wake cycle is governed by whether you are nocturnal or not, and that governs your BG when you wake.

It’s fairly easy to change your sleep/wake cycle, but it takes at least a month to do it. Folk working permanent nights, like some nurses and railway repairmen, can get into a decent rhythm, and will show the Dawn Phenomenon in the evening, just like these mice. It’s folk who work a split shift, or a week on and a week off, and all the other varieties like 06.00 to 14.00, 14.00 to 22.00, and 22.00 to 06.00 shifts beloved by 24 hour factories that really affect the sleep/wake cycle badly, but it’s still all squeezed into the normal circadian cycle of 24 hours. Fiddle with that at your peril.

We are all getting our sleep/wake cycles tinkered with by the government stealing an hour’s sleep tonight. An almost completely useless tinkering, especially in Northern parts. And bloody annoying fixing the time on my Libre reader, my phone does it automatically. As do most of my electronic gadgets. It’s just the oven and the Libre reader that need changing.😡
 
mikeyB said:
We are all getting our sleep/wake cycles tinkered with by the government stealing an hour’s sleep tonight. An almost completely useless tinkering, especially in Northern parts. And bloody annoying fixing the time on my Libre reader, my phone does it automatically. As do most of my electronic gadgets. It’s just the oven and the Libre reader that need changing.😡
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My brain gets very confused by all this 😱 My oven is now showing the correct time 😉

I would highly recommend 'Why We Sleep' by Matthew Walker - I take my sleep much more seriously after reading it 🙂
 
I don’t have any problems sleeping. Too busy reading Carlo Rovelli’s Helgoland to get up to speed on Quantum Gravity, so no need to know why we sleep. I already know, my body has explained it to me 🙂
 
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