Oh yeah, it surely can. A couple of weeks back I went really high and my bro found me standing in the middle of the sitting room a complete blank. He couldn't get me to react for a few minutes. I have no recollection of this, or the visit to the hospital that followed it.
On a good day, I routinely forget to take my pills, or I did until my OH set reminders on my phone for me. Why didn't I think of that? I used to pride myself on my phenomenal memory, but now information slips away like sand through the holes in a colander. I struggle for words I should know well, the simplest ones some times. I scares me that my braincells seem to be leaking out through my ears. The sooner I get this thrice damned disease under control the better, I'm assured things should improve when I do.