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The enzyme that 'loads up' fat-carrying particles in the liver before they are transported around the body has been identified for the first time by scientists at the University of Warwick.
The discovery also reveals how to 'slim down' these particles to reduce the amount of the worst type of 'bad' cholesterol distributed throughout the body and could pave the way for new treatments to prevent heart disease and strokes.
A study published by Professor Victor Zammit from Warwick Medical School in the Journal of Lipid Research examined the effects of inhibiting the production of the enzyme diacylglycerol acyltransferase 1 (DGAT1). This enzyme is present in the liver and is associated with the production of Very Low-Density Lipoproteins (VLDL). These contain fat in the form of triglycerides choesterylesters, cholesterol, and are surrounded by proteins and charged lipids.
https://www.sciencedaily.com/releases/2019/01/190128101114.htm
The discovery also reveals how to 'slim down' these particles to reduce the amount of the worst type of 'bad' cholesterol distributed throughout the body and could pave the way for new treatments to prevent heart disease and strokes.
A study published by Professor Victor Zammit from Warwick Medical School in the Journal of Lipid Research examined the effects of inhibiting the production of the enzyme diacylglycerol acyltransferase 1 (DGAT1). This enzyme is present in the liver and is associated with the production of Very Low-Density Lipoproteins (VLDL). These contain fat in the form of triglycerides choesterylesters, cholesterol, and are surrounded by proteins and charged lipids.
https://www.sciencedaily.com/releases/2019/01/190128101114.htm
