Eddy Edson
Well-Known Member
- Relationship to Diabetes
- Type 2
New review: https://diabetesjournals.org/care/a...ypical-Diabetes-What-Have-We-Learned-and-What
As our understanding of the pathophysiology of diabetes evolves, we increasingly recognize that many patients may have a form of diabetes that does not neatly fit with adiagnosis of either type 1 or type 2 diabetes. The discovery and description of theseforms of “atypical diabetes” have led to major contributions to our collective understanding of the basic biology that drives insulin secretion, insulin resistance, and isletautoimmunity.These discoveries now pave the way to a better classification of diabetesbased on distinct endotypes. In this review, we highlight the key biological and clinicalinsights that can be gained from studying known forms of atypical diabetes. Additionally, we provide a framework for identification of patients with atypical diabetes basedon their clinical, metabolic, and molecular features. Helpful clinical and genetic resources for evaluating patients suspected of having atypical diabetes are provided. Therefore, appreciating the various endotypes associated with atypical diabetes will enhancediagnostic accuracy and facilitate targeted treatment decisions.
As our understanding of the pathophysiology of diabetes evolves, we increasingly recognize that many patients may have a form of diabetes that does not neatly fit with adiagnosis of either type 1 or type 2 diabetes. The discovery and description of theseforms of “atypical diabetes” have led to major contributions to our collective understanding of the basic biology that drives insulin secretion, insulin resistance, and isletautoimmunity.These discoveries now pave the way to a better classification of diabetesbased on distinct endotypes. In this review, we highlight the key biological and clinicalinsights that can be gained from studying known forms of atypical diabetes. Additionally, we provide a framework for identification of patients with atypical diabetes basedon their clinical, metabolic, and molecular features. Helpful clinical and genetic resources for evaluating patients suspected of having atypical diabetes are provided. Therefore, appreciating the various endotypes associated with atypical diabetes will enhancediagnostic accuracy and facilitate targeted treatment decisions.
