Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
A pair of studies by researchers at the Stanford University School of Medicine has identified a molecular pathway -- a series of interaction among proteins -- involved in the development of diabetes. Furthermore, they have found that a drug already approved for use in humans can regulate the pathway.
The findings will be published online Sept. 15 in two articles in Nature Medicine.
The studies, done in mice, identify a previously unexpected link between a low-oxygen condition called hypoxia and the ability of cells in the liver to respond to insulin. The drug, aflibercept (marketed as Eylea or Zaltrap), is used to treat metastatic colorectal cancer and a form of macular degeneration. Aflibercept is a member of a family of proteins that inhibit the vascular endothelial growth factor, or VEGF, pathway. It works by blocking the growth of the blood vessels into tumors and starving them of oxygen.
http://www.sciencedaily.com/releases/2013/09/130915134355.htm
The findings will be published online Sept. 15 in two articles in Nature Medicine.
The studies, done in mice, identify a previously unexpected link between a low-oxygen condition called hypoxia and the ability of cells in the liver to respond to insulin. The drug, aflibercept (marketed as Eylea or Zaltrap), is used to treat metastatic colorectal cancer and a form of macular degeneration. Aflibercept is a member of a family of proteins that inhibit the vascular endothelial growth factor, or VEGF, pathway. It works by blocking the growth of the blood vessels into tumors and starving them of oxygen.
http://www.sciencedaily.com/releases/2013/09/130915134355.htm