Adenovirus the Leading Suspect in Child Hepatitis Investigation

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Adenovirus remained the most likely underlying factor responsible for the outbreak of sudden onset hepatitis in children, UK public health experts have said.

Investigations are still ongoing into whether a cofactor could cause a normal adenovirus to produce a more severe clinical presentation, the UK Health Security Agency (UKHSA) said in an update on Monday.

A further three confirmed cases of acute non-A-E hepatitis in children with serum transaminases greater than 500 IU/L have been identified since the Agency's last briefing on April 21, bringing the total number of known cases to 111. Of those, 81 were in England, 14 in Scotland, 11 in Wales, and 5 in Northern Ireland.

No deaths in the UK have occurred, but a total of 10 children affected subsequently received a liver transplant. Of the cases in England, 43 individuals had recovered.

 
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