Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Higher insulin use doesn't account for the higher mortality risk with intensive glucose management in the ACCORD trial, a subanalysis determined, although whether those results were reassuring for the clinic was subject to debate.
Each unit of insulin per kilogram body weight was associated with an 83% higher unadjusted risk of cardiovascular mortality in the trial, Elias Siraj, MD, of Temple University in Philadelphia, and colleagues reported here at the American Diabetes Association meeting.
But that association was attenuated down to a nonsignificant 12% difference after adjustment for other medication differences and clinical characteristics, and disappeared entirely after additional control for treatment arm in the trial, suggesting no independent impact.
http://www.medpagetoday.com/MeetingCoverage/ADA/40107
Each unit of insulin per kilogram body weight was associated with an 83% higher unadjusted risk of cardiovascular mortality in the trial, Elias Siraj, MD, of Temple University in Philadelphia, and colleagues reported here at the American Diabetes Association meeting.
But that association was attenuated down to a nonsignificant 12% difference after adjustment for other medication differences and clinical characteristics, and disappeared entirely after additional control for treatment arm in the trial, suggesting no independent impact.
http://www.medpagetoday.com/MeetingCoverage/ADA/40107