Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Youth with type 1 diabetes show abnormal plasma glucagon responses to mixed meal tolerance tests within two years after diagnosis, according to researchers from the Diabetes Research in Children Network (DirecNet).
"Our findings demonstrate that dysregulation in glucagon secretion is seen early in the course of disease, being demonstrated in some of our subjects within the first year after diagnosis," said Dr. Jennifer Sherr from Yale University School of Medicine in New Haven, Connecticut.
"These data provide compelling evidence for the use of adjunctive therapies that suppress glucagon secretion in youth regardless of disease duration," she told Reuters Health by email.
In many patients with type 1 diabetes, exaggerated alpha-cell responses to amino acid stimulation, manifested by higher glucagon levels, may contribute to postprandial hyperglycemia.
http://www.medscape.com/viewarticle/823964
(free registration)
"Our findings demonstrate that dysregulation in glucagon secretion is seen early in the course of disease, being demonstrated in some of our subjects within the first year after diagnosis," said Dr. Jennifer Sherr from Yale University School of Medicine in New Haven, Connecticut.
"These data provide compelling evidence for the use of adjunctive therapies that suppress glucagon secretion in youth regardless of disease duration," she told Reuters Health by email.
In many patients with type 1 diabetes, exaggerated alpha-cell responses to amino acid stimulation, manifested by higher glucagon levels, may contribute to postprandial hyperglycemia.
http://www.medscape.com/viewarticle/823964
(free registration)
