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A third of trials involving breast cancer treatments have evidence of spin or bias in their reporting, raising questions over the benefits of treatments, according to a new review.
Canadian oncologists found 33% of breast cancer clinical trial papers were reported as having positive results despite not showing a statistically significant difference in the primary end point.
In their findings, published in the journal Annals of Oncology this week, they also found two-thirds of studies showed bias by under-reporting the toxic effects of treatment.
The findings come from a review of 164 randomised controlled Phase III trials of breast cancer treatments by researchers at the Princess Margaret Cancer Centre, Toronto, and the University of Toronto, Canada.
http://www.pulsetoday.co.uk/clinica...trials-have-evidence-of-bias/20001415.article
(free registration required)
Canadian oncologists found 33% of breast cancer clinical trial papers were reported as having positive results despite not showing a statistically significant difference in the primary end point.
In their findings, published in the journal Annals of Oncology this week, they also found two-thirds of studies showed bias by under-reporting the toxic effects of treatment.
The findings come from a review of 164 randomised controlled Phase III trials of breast cancer treatments by researchers at the Princess Margaret Cancer Centre, Toronto, and the University of Toronto, Canada.
http://www.pulsetoday.co.uk/clinica...trials-have-evidence-of-bias/20001415.article
(free registration required)