A study finds statin treatment not associated with some adverse neuropsychiatric outcomes

[Eddy Edson]

Statin treatment not associated with adverse neuropsychiatric outcomes

Statin use did not appear associated with suicidality, anxiety disorders or seizures, according to results of a total-population cohort study published in The Lancet Psychiatry. “The differential effects of statins on depression and seizures have been attributed to structural differences between...

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In the current study, the investigators used Swedish national registers to link data on dispensed statin prescriptions with data on unplanned hospital visits or specialized outpatient care for neuropsychiatric outcomes, including suicidal behavior, depressive disorders, anxiety disorders and seizures. Data were available of 1,149,384 individuals who were dispensed statins and aged 15 years or older between 2006 and 2013.

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“We found no associations between statin treatment and suicidal outcomes, anxiety disorders or seizures, suggesting that statin treatment is a safe therapeutic option with regard to some neuropsychiatric outcomes,” Molero and colleagues wrote. “We observed a reduction in the risk [for] depressive disorders during periods of statin treatment, but a similar (albeit non-significant) reduction was seen during treatments with two other non-psychotropic medications, and this association requires further investigation to clarify the possible contribution of nonspecific treatment factors.”

 

[mikeyB]

I await with interest the response of folk on the forum who have had psychological problems they got after starting statins which disappeared after stopping them...

 

[Eddy Edson]

I await with interest the response of folk on the forum who have had psychological problems they got after starting statins which disappeared after stopping them...

Of course these things are always at the population level, with 95% confidence intervals for HR's going a bit below 1 to a bit above. Individuals live in that "bit above 1" ...

 

[Robin]

It does say a safe option regarding 'some' neuropsychiatric outcomes. If I remember rightly, members of this forum seem have had problems relating more to memory loss.

 

[Eddy Edson]

It does say a safe option regarding 'some' neuropsychiatric outcomes. If I remember rightly, members of this forum seem have had problems relating more to memory loss.

I actually added "some" to the title - the original title made it seem more like "all", a bit misleading.

 

[Amigo]

I’d have ended up with psychiatric problems if I’d continued on them given the massive adverse impact they had on my muscles and joints! I was persuaded to give them a try recently but within days could barely function or lift my arms. Statins discontinued. I’ll have to take my chances without! 🙄

 

[grovesy]

I’d have ended up with psychiatric problems if I’d continued on them given the massive adverse impact they had on my muscles and joints! I was persuaded to give them a try recently but within days could barely function or lift my arms. Statins discontinued. I’ll have to take my chances without! 🙄

I even used the term quality of life to my then DiabetesNurse.