Amity Island
Well-Known Member
- Relationship to Diabetes
- Type 1
Research led by Young lab postdocs Alessandra Dall’Agnese and Jesse Platt and research scientist Tony Lee has uncovered a molecular mechanism underlying type 2 diabetes. The new finding, made in collaboration with researchers from the labs of Jaenisch and Massachusetts Institute of Technology (MIT) Professors Linda Griffith and Ibrahim Cissé, reveals that insulin receptors, the signaling molecules that sense insulin, normally function by clustering together in cells and that this clustering is defective in insulin resistance, the basis of type 2 diabetes.
Their discovery also helps explain a mystery about how therapeutic treatment by metformin, the frontline drug for diabetes, works in patients. The researchers hope that these insights, published in Nature Communications on December 6, will bring about a better understanding of diabetes at a molecular level and lead to the development of new therapies.
wi.mit.edu
Their discovery also helps explain a mystery about how therapeutic treatment by metformin, the frontline drug for diabetes, works in patients. The researchers hope that these insights, published in Nature Communications on December 6, will bring about a better understanding of diabetes at a molecular level and lead to the development of new therapies.
Whitehead Institute of MIT
Whitehead Institute researchers have uncovered a molecular mechanism underlying type 2 diabetes. The new finding reveals that insulin receptors, the signaling molecules that sense insulin, normally function by clustering together in cells and that this clustering is defective in insulin...
