Hi, I'm Angela. Usually 17 units at 9am, and 7 units at 6pm. Humulin M3 KwikPen. Awoke very late today. Took 12 units at 11.45am. Blood glucose perfect, as usually is. Plan to take 7 units at 7pm. Will be up very late again as usual so should be OK, but what do you think please? Advice welcome 🙂)
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Overslept.. help!
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trophywench
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Sorry Angela I'm no expert on mixed insulin - been 20 years since I was on it.
Depends what time you eat really cos the fast acting element of the second jab might come too soon for the food or something. How about delaying the evening jab by an hour?
Depends what time you eat really cos the fast acting element of the second jab might come too soon for the food or something. How about delaying the evening jab by an hour?
Copepod
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You probably already know about Humalin M3 twin peaks of activity, but I feel it's important to cover the basics first in answer to your question. Taken from page http://www.netdoctor.co.uk/diabetes/medicines/humulin-m3.html the key passage is:
"Humulin M3 contains a mix of two types of insulin, soluble insulin and isophane insulin. Together, this combination of insulin is called biphasic isophane insulin. Humulin M3 contains 30% soluble insulin and 70% isophane insulin.
Soluble insulin is known as a short-acting insulin. It starts to works quickly, within 30 to 60 minutes, and its effects last for about eight hours. Isophane insulin is known as an intermediate-acting insulin. It takes longer to act, but its effects last longer. The pre-mixed combination provides a rapid initial blood glucose lowering effect, followed by a prolonged effect that controls blood glucose throughout the day. It is usually injected under the skin approximately 30 minutes before a meal.
Read more: http://www.netdoctor.co.uk/diabetes/medicines/humulin-m3.html#ixzz3PCrXZkkx"
The downsides of biphasic insulin is that you commit yourself for your next two meals / snacks, both amount of carbohydrate and timing, with each injection. The risk is you may take your second injection of the day before the first is out of your system or on the way out. So, it would have been preferable to have delayed your 7pm dose. Sorry, I know it's too late to say that now, but I was driving up the M1 when you posted and have only just sat down to some web browsing.
"Humulin M3 contains a mix of two types of insulin, soluble insulin and isophane insulin. Together, this combination of insulin is called biphasic isophane insulin. Humulin M3 contains 30% soluble insulin and 70% isophane insulin.
Soluble insulin is known as a short-acting insulin. It starts to works quickly, within 30 to 60 minutes, and its effects last for about eight hours. Isophane insulin is known as an intermediate-acting insulin. It takes longer to act, but its effects last longer. The pre-mixed combination provides a rapid initial blood glucose lowering effect, followed by a prolonged effect that controls blood glucose throughout the day. It is usually injected under the skin approximately 30 minutes before a meal.
Read more: http://www.netdoctor.co.uk/diabetes/medicines/humulin-m3.html#ixzz3PCrXZkkx"
The downsides of biphasic insulin is that you commit yourself for your next two meals / snacks, both amount of carbohydrate and timing, with each injection. The risk is you may take your second injection of the day before the first is out of your system or on the way out. So, it would have been preferable to have delayed your 7pm dose. Sorry, I know it's too late to say that now, but I was driving up the M1 when you posted and have only just sat down to some web browsing.
Copepod
Much missed Moderator
- Relationship to Diabetes
- Type 1
Glad you found the link useful. Just sorry there was not answer in time for appropriate action. I'd be tempted to check before bedtime, and have a snack, in case levels fall overnight - you might go a bit high, but safer than going hypo in your sleep.
In the longer term, basal bolus / MDI regime of 1 or 2 long acting insulin injections per day and short acting with each meal, usually 3 per day, gives more flexibility, so may be worth considering, if your lifestyle involves different times of sleeping, eating, working etc.
In the longer term, basal bolus / MDI regime of 1 or 2 long acting insulin injections per day and short acting with each meal, usually 3 per day, gives more flexibility, so may be worth considering, if your lifestyle involves different times of sleeping, eating, working etc.
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